Identifier
Cysteamine aminoethanethiol thioethanolamine is a metabolic product of the amino acid cysteine.
In medicine, cysteamine is used to treat cystine excretion disorders (cystinosis), cystic fibrosis, Batten’s disease, Huntington’s disease and infectious diseases. Radiation.
The weight gain stimulating effect is related to growth hormone. Experiments show that Cysteamine can help porkers gain weight by over 33%, increase lean rate by 4-6%, and reduce weight. Fat percentage 8 5% compared to control….
How does Cysteamine work and how does it increase weight?
Growth Hormone GH secreted by the pituitary gland stimulates the growth of whole body tissues: bone, muscle, fat… At the same time, it stimulates the liver and some tissues to produce IGF-1. The hormone IGF-1 controls the hematopoietic organs in the spleen bone marrow…
GH secretion is increased thanks to GHRH (growth hormone releasing hormone) and its inhibition is reduced by GHRIH (growth hormone release inhibiting hormone), also known as SS (somatostatin) or SRIF (somatotropin realease inhibitory factor; thus always stabilizing the balance of development.
Cysteamine has the effect of inhibiting the effects of SS, allowing the growth hormone GH to work freely. Animals fed cysteamine-containing food will grow quickly, gain weight and increase lean mass.
Experiments conducted in China showed that feeding chickens and ducks with food supplemented with cysteamine at a dosage of 400mg/kg of food will help chickens and ducks gain weight by 5-17%. Surveys on pigs With a dosage of 500mg/kg of feed, it can help pigs increase weight gain from 14% to 33%, increase leanness by 4-6% and reduce fat by 8-5%
And the effects harmful…
In the body, cysteamine inhibits the enzyme glutathione peroxidase, causing the production of hydrogen peroxide (hydroperoxide H2O2) that is toxic to cells.
The use of cysteamine to Gaining weight and creating leanness in animals leads to a sudden increase in growth hormones, leading to an increase and residue of IGF-1 in the body. Many studies show that IGF-1 residue in milk can cause risks cancer breast colon and prostate cancer in humans.
Although there is no research confirming the existence Excess IGF-1 in chicken meat and viscera can pose a cancer risk to humans, but studies on mice show that using cysteamine can cause the production of derivatives such as toluene dopamine antagonist or MPTP (1- methyl-4 phenyl 1 2 3 6 tetrahydropyridine) are neurotoxic and cause duodenal ulcers in rats. 50% lethal dose (LD50) in rats: oral dose is 625 mg/kg body weight; Intravenous injection is 190 mg/kg, intraperitoneal injection is 250 mg/kg and subcutaneous injection is 84 mg/kg.
According to the Institute of Veterinary Medicine, Ministry of Agriculture and Rural Development, cysteamine when used as a feed additive raised to stimulate growth, people who eat meat containing this substance for a long time are susceptible to diseases such as breast cancer, colon and prostate cancer, weakened immune system…
A few things to discuss
Currently many countries in the world such as Thailand Malaysia Canada USA Austrailia Japan… cysteamine is not on the list of banned substance used in animal feed. Even in Europe, cysteamine has not been included in the list of banned substances. Since 1996, Europe has only regulated the use of substances with hormonal activity to stimulate animal growth. China is the only country that allows the use of cysteamine as an animal feed additive.
Mr. Hoang Thanh Van, Director of the Department of Livestock Production, said that the Department is drafting a Circular to include Cysteamine in the list. banned substances used in animal feed and at the same time carry out procedures to designate a cysteamine analysis laboratory to manage food hygiene and safety. Expected to be completed in December 2016.
In my opinion, except for “clean” biological methods to gain weight and create lean mass such as using micronutrients… these methods of gaining weight are “problematic”. such as using beta agonists (salbutamol) or cysteamine… should all be banned or strictly controlled.
Dr. Tran Ba Thoai
Vietnam Endocrine Association
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